Analysis of β/α Globin Ratio by Using Relative qRT-PCR for Diagnosis of Beta-Thalassemia Carriers
نویسندگان
چکیده
منابع مشابه
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در این پایان نامه نشان داده ایم که چگونه می توان مدل ریسک بیمه ای اسپیرر اندرسون را به کمک زنجیره های مارکوف تعریف کرد. سپس به کمک روش های آنالیز ماتریسی احتمال برشکستگی ، میزان مازاد در هنگام برشکستگی و میزان کسری بودجه در زمان وقوع برشکستگی را محاسبه کرده ایم. هدف ما در این پایان نامه بسیار محاسباتی و کاربردی تر از روش های است که در گذشته برای محاسبه این احتمال ارائه شده است. در ابتدا ما نشا...
15 صفحه اولComparisons between RT-PCR, real-time PCR, and in vitro globin chain synthesis by α/β ratio calculation for diagnosis of α- from β-thalassemia carriers.
BACKGROUND Thalassemia, which may be due to point mutations, translocations, and deletions involving the α or βglobin gene, is the most prevalent single gene disorder in Iran.This study aims to calculate the α/β ratio in normal cases, α- and β-thalassemia carriers by RT-PCR, real-time PCR, and in vitro globin chain synthesis (GCS) in order to establish the most accurate technique to distinguish...
متن کاملComparisons between RT-PCR, Real-time PCR, and In Vitro Globin Chain Synthesis by a/b Ratio Calculation for Diagnosis of a- from b-thalassemia Carriers
T halassemia syndromes are the most prevalent autosomal recessive single gene disorders in Iran.1,2 Interactions of different types of hemoglobinopathies can lead to thalassemia syndromes with a variety of phenotypes that range from asymptomatic to severe anemia. The diversity of thalassemia phenotypes depends on the amount of imbalances created between and non-globin chains.3,4 In normal eryth...
متن کاملdetection of unknown deletions in alpha globin genes in alpha thalassemia carriers using real-time pcr
objective: alpha-thalassemia is one of the most prevalent hemoglobin disorders in the world and it is a common hereditary condition caused by deletion of one or more α-globin genes. common α-thalassemia deletions like 3.7 kb, 4.2 kb, 20.5 kb and med can be detected by multiplex pcr. there are, however, some unknown deletions that can not be detected by the mentioned method or even by direct dna...
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ژورنال
عنوان ژورنال: Journal of Clinical Laboratory Analysis
سال: 2013
ISSN: 0887-8013
DOI: 10.1002/jcla.21594